diff --git a/src/dbus_fast/aio/message_bus.py b/src/dbus_fast/aio/message_bus.py
index 71b97eb..e4bb466 100644
--- a/src/dbus_fast/aio/message_bus.py
+++ b/src/dbus_fast/aio/message_bus.py
@@ -4,7 +4,7 @@ import logging
 import socket
 from collections import deque
 from copy import copy
-from typing import Any, List, Optional, Tuple
+from typing import Any, Callable, List, Optional, Set, Tuple
 
 from .. import introspection as intr
 from ..auth import Authenticator, AuthExternal
@@ -18,7 +18,7 @@ from ..constants import (
 )
 from ..errors import AuthError
 from ..message import Message
-from ..message_bus import BaseMessageBus
+from ..message_bus import BaseMessageBus, _block_unexpected_reply
 from ..service import ServiceInterface
 from .message_reader import build_message_reader
 from .proxy_object import ProxyObject
@@ -173,7 +173,7 @@ class MessageBus(BaseMessageBus):
     :vartype connected: bool
     """
 
-    __slots__ = ("_loop", "_auth", "_writer", "_disconnect_future")
+    __slots__ = ("_loop", "_auth", "_writer", "_disconnect_future", "_pending_futures")
 
     def __init__(
         self,
@@ -193,6 +193,7 @@ class MessageBus(BaseMessageBus):
             self._auth = auth
 
         self._disconnect_future = self._loop.create_future()
+        self._pending_futures: Set[asyncio.Future] = set()
 
     async def connect(self) -> "MessageBus":
         """Connect this message bus to the DBus daemon.
@@ -431,12 +432,33 @@ class MessageBus(BaseMessageBus):
         if not asyncio.iscoroutinefunction(method.fn):
             return super()._make_method_handler(interface, method)
 
-        def _coro_method_handler(msg, send_reply):
-            def done(fut):
+        negotiate_unix_fd = self._negotiate_unix_fd
+        msg_body_to_args = ServiceInterface._msg_body_to_args
+        fn_result_to_body = ServiceInterface._fn_result_to_body
+
+        def _coroutine_method_handler(
+            msg: Message, send_reply: Callable[[Message], None]
+        ) -> None:
+            """A coroutine method handler."""
+            args = msg_body_to_args(msg) if msg.unix_fds else msg.body
+            fut = asyncio.ensure_future(method.fn(interface, *args))
+            # Hold a strong reference to the future to ensure
+            # it is not garbage collected before it is done.
+            self._pending_futures.add(fut)
+            if (
+                send_reply is _block_unexpected_reply
+                or msg.flags.value & NO_REPLY_EXPECTED_VALUE
+            ):
+                fut.add_done_callback(self._pending_futures.discard)
+                return
+
+            # We only create the closure function if we are actually going to reply
+            def _done(fut: asyncio.Future) -> None:
+                """The callback for when the method is done."""
                 with send_reply:
                     result = fut.result()
-                    body, unix_fds = ServiceInterface._fn_result_to_body(
-                        result, method.out_signature_tree
+                    body, unix_fds = fn_result_to_body(
+                        result, method.out_signature_tree, replace_fds=negotiate_unix_fd
                     )
                     send_reply(
                         Message.new_method_return(
@@ -444,11 +466,11 @@ class MessageBus(BaseMessageBus):
                         )
                     )
 
-            args = ServiceInterface._msg_body_to_args(msg)
-            fut = asyncio.ensure_future(method.fn(interface, *args))
-            fut.add_done_callback(done)
+            fut.add_done_callback(_done)
+            # Discard the future only after running the done callback
+            fut.add_done_callback(self._pending_futures.discard)
 
-        return _coro_method_handler
+        return _coroutine_method_handler
 
     async def _auth_readline(self) -> str:
         buf = b""
diff --git a/src/dbus_fast/message_bus.py b/src/dbus_fast/message_bus.py
index 8248105..98c23d4 100644
--- a/src/dbus_fast/message_bus.py
+++ b/src/dbus_fast/message_bus.py
@@ -770,24 +770,27 @@ class BaseMessageBus:
         if not msg.serial:
             msg.serial = self.next_serial()
 
-        def reply_notify(reply: Optional[Message], err: Optional[Exception]) -> None:
-            if reply and msg.destination and reply.sender:
-                self._name_owners[msg.destination] = reply.sender
-            callback(reply, err)  # type: ignore[misc]
-
         no_reply_expected = not _expects_reply(msg)
-
         # Make sure the return reply handler is installed
         # before sending the message to avoid a race condition
         # where the reply is lost in case the backend can
         # send it right away.
         if not no_reply_expected:
-            self._method_return_handlers[msg.serial] = reply_notify
+
+            def _reply_notify(
+                reply: Optional[Message], err: Optional[Exception]
+            ) -> None:
+                """Callback on reply."""
+                if reply and msg.destination and reply.sender:
+                    self._name_owners[msg.destination] = reply.sender
+                callback(reply, err)
+
+            self._method_return_handlers[msg.serial] = _reply_notify
 
         self.send(msg)
 
         if no_reply_expected:
-            callback(None, None)  # type: ignore[misc]
+            callback(None, None)
 
     @staticmethod
     def _check_callback_type(callback: Callable) -> None:
@@ -921,7 +924,9 @@ class BaseMessageBus:
         def _callback_method_handler(
             msg: Message, send_reply: Callable[[Message], None]
         ) -> None:
-            result = method_fn(interface, *msg_body_to_args(msg))
+            """This is the callback that will be called when a method call is."""
+            args = msg_body_to_args(msg) if msg.unix_fds else msg.body
+            result = method_fn(interface, *args)
             if send_reply is BLOCK_UNEXPECTED_REPLY or not _expects_reply(msg):
                 return
             body, fds = fn_result_to_body(
diff --git a/src/dbus_fast/service.py b/src/dbus_fast/service.py
index 19226a1..8868531 100644
--- a/src/dbus_fast/service.py
+++ b/src/dbus_fast/service.py
@@ -490,9 +490,7 @@ class ServiceInterface:
 
     @staticmethod
     def _msg_body_to_args(msg: Message) -> List[Any]:
-        if not msg.unix_fds or not signature_contains_type(
-            msg.signature_tree, msg.body, "h"
-        ):
+        if not signature_contains_type(msg.signature_tree, msg.body, "h"):
             return msg.body
 
         # XXX: This deep copy could be expensive if messages are very